Influence of tobacco smoking on the state of endothelial function in residents of the Arctic zone of Western Siberia

The effect of smoking on the violation of the endothelial function of blood vessels, leading to increasing stiffness of blood vessels and increasing the flow velocity leads to the violation of the adequacy of the blood supply to the organs and systems. This is an important factor in the development of a number of chronic non-communicable diseases, which make up approximately 80% of the mortality rate in Russia. We examined a total of 367 residents (29.7% of men, mean age of 47.8±13.5 years) during research expeditions in the village of Krasnosel’kup, village of Tolka and Ratta of Krasnoselkupsky district. The state of the vascular system, its ability to provide adequate blood supply to organs and tissues, was studied by the parameters of the vascular stiffness index (blood flow rate, SI, m/s). We studied a sample of values of the index of rigidity of vessels of above normal occur significantly more often among smokers of the respondents (U-7103.5; p=0.02) than non-smokers. In the analysis of the parameters of the reflection index of the vessel (RI%) in the studied by us sample values above the norm were significantly more often found among smokers (U=5578.0; p