Abstract 21: Effects of the Selective NLRP3-Inflammasome Inhibitor MCC950 on Post-Resuscitation Myocardial and Cerebral Function in a Rat Model of Cardiopulmonary Resuscitation

Guanghui Zheng,Jing Xu,Fenglian He,Juntao Hu,Weiwei Ge,Xianfei Ji,Jennifer Bradley,Mary Ann Peberdy,Joseph P. Ornato,Longyuan Jiang,Tong Wang,Stefano Toldo,Wanchun Tang

Abstract 21: Effects of the Selective NLRP3-Inflammasome Inhibitor MCC950 on Post-Resuscitation Myocardial and Cerebral Function in a Rat Model of Cardiopulmonary Resuscitation

2019

Guanghui Zheng
Jing Xu
Fenglian He
Juntao Hu
Weiwei Ge
Xianfei Ji
Jennifer Bradley
Mary Ann Peberdy
Joseph P. Ornato
Longyuan Jiang
Tong Wang
Stefano Toldo
Wanchun Tang

Introduction: NLRP3 inflammasome mediated pyroptosis has been demonstrated to increase myocardial and cerebral ischemia/reperfusion injury. MCC950 is a newly developed highly selective inhibitor of...

Keywords:

Ejection fraction
Internal medicine
Ischemia
Cardiology
Resuscitation
Diabetes mellitus
Inflammasome
Reperfusion injury
Cardiopulmonary resuscitation
Pyroptosis
Medicine
rat model

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