Research progress of mitochondria-related microRNA in non-alcoholic fatty liver disease

Mitochondrial dysfunction is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) by causing insulin resistance, fat changes and oxidative stress in the liver. Recent studies have shown that microRNA (miRNA) can regulate a variety of biological functions and is related to a variety of diseases including NAFLD, which is caused by mitochondria-related miRNA through regulation of cytokines, fatty acid oxidation, mitochondrial complex and oxidative stress. Until now, no therapeutic treatments have proven effective for the treatment of NAFLD. However, the studies of mitochondria-related miRNA in NAFLD suggest that it may provide a new direction for the diagnosis and treatment of NAFLD. Key words: Non-alcoholic fatty liver disease; Mitochondria; Mitochondria-related miRNA