The change and clinical significance of Fib、PT、APTT and D-dimer in acute stroke

Objective: To explore the changes of Fib、PT、APTT and D-dimer in acute stroke and their clinical significance. Methods: The levels of Fib、PT、APTT and D-dimer were investigated 82 cases acute cerebral infarctions and 66 cases acute cerebral hemorrhages on the days of 1 、3、7、14 d after getting ill, and the results were compared with the data from 50 cases healthy people. Rusults: The levels of Fib and D-dimer in the acute stroke group tested on the 1 、3、7 d were all higher than those of the contrastive group (P0.05). A positive correlation was shown between Fib and D-dimer. The levels of PT and APTT in the acute stroke group had no obvious difference from those of the contrastive group ( P 0.05). Conclusion: The levels of Fib and D-dimer in acute stroke group are all higher than those of the contrastive group. It indicates that coagulation disorder may be associated with the occurrence of acute stroke, and suggests that Fib and Ddimer will serve as one of the objective indicators for predictiing the stoke and evaluating the effectiveness of stoke therapy.