Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance

### What you need to know The UK vaccination programme has prevented thousands of deaths from infection with SARS-CoV-2, but has been accompanied by new vaccine related complications. The most serious of these is a novel disorder, described as vaccine induced immune thrombocytopenia and thrombosis (VITT). This immune mediated condition is caused by development of pathological anti-platelet factor 4 (PF4) antibodies following vaccination against covid-19, which leads to intense activation of platelets and the coagulation system. The subsequent clinical syndrome often presents with life threatening thrombosis and secondary haemorrhage, which are challenging to manage in the context of new biochemical coagulopathy. This article summarises the most recent recommendations from the rapid covid-19 guideline produced by the National Institute for Health and Care Excellence (NICE).1 NICE recommendations are based on systematic reviews of best available evidence. This guideline was developed using an interim process and methods for guidelines developed in response to health and social care emergencies. These included convening an independent advisory expert panel, scoping, identifying, and reviewing …