T1987 Mucous Metaplasia Confers An ER Stress in Helicobacter-Related Gastric Carcinogenesis

INTRODUCTION: Colorectal adenoma is known to be associated with obesity, but the association between it and visceral adipose tissue (VAT) area measured by abdominal CT has not been clearly documented. In addition, the relationship between insulin resistance and colorectal adenoma, which underlies the mechanism that links obesity and colorectal adenoma has not been revealed by any epidemiologic study. AIM: To examine VAT area and insulin resistance as risk factors of colorectal adenoma. METHODS: A cross-sectional, case-control study was conducted in Koreans that presented for health check-ups. Subjects underwent various laboratory tests, abdominal CT and colonoscopy. VAT, subcutaneous adipose tissue (SAT) and HOMA index were evaluated as potential risk factors of colorectal adenoma in 2,244 age and sex matched subjects. RESULTS: According to univariate analysis, the prevalence of smoking, hypertension, metabolic syndrome and family history of colorectal cancer were higher in the adenoma group than in the normal control group. In addition, body mass index, waist circumference, triglyceride, high-density lipoprotein cholesterol, VAT and SAT areas were significantly different in the two groups. According to multivariate analysis adjusted for multiple confounders, VAT area was independently associated with the risk of colorectal adenoma (OR=2.66, 95% CI: 1.79-3.95, lowest quintile vs. highest quintile). Mean HOMA index was higher in the adenoma group than in the control group (OR=1.53, 95% CI: 1.08-2.16, lowest vs. highest quintile). CONCLUSION: Visceral obesity was found to be an independent risk factor of colorectal adenoma, and insulin resistance was associated with the presence of colorectal adenoma.