Transplant Aspiration Cytology for Monitoring of Kidney Xenograft (Wolf-Dog) under Cyclosporin A Treatment

Mongrel dogs receiving wolf kidney grafts were treated with Cyclosporin A. The kinetics of the inflammatory response and the display of major histocompatibility (MHC) antigens on graft tubular cells were analyzed by transplant aspiration cytology. Tubular cells aspirated from grafts that underwent repeated rejection episodes showed a higher degree of MHC antigen expression than cells obtained from a well-functioning graft.