Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes

Andrea Sorrentino,Giulia Borghetti,Yu Zhou,Antonio Cannata,Marianna Meo,Sergio Signore,Piero Anversa,Annarosa Leri,Polina Goichberg,Khaled Qanud,Jason T. Jacobson,Thomas H. Hintze,Marcello Rota

Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes

2017

Andrea Sorrentino
Giulia Borghetti
Yu Zhou
Antonio Cannata
Marianna Meo
Sergio Signore
Piero Anversa
Annarosa Leri
Polina Goichberg
Khaled Qanud
Jason T. Jacobson
Thomas H. Hintze
Marcello Rota

We have investigated the effects of hyperglycemia on cardiomyocyte physiology and ventricular function. Our results indicate that defective Ca2+ handling is a critical component of the progressive deterioration of cardiac performance of the diabetic heart.

Keywords:

Homeostasis
Myocyte
Diabetes mellitus
Endocrinology
Biology
Internal medicine
ventricular function
ca2 homeostasis
calcium handling
Medicine

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