Effects of the polymorphisms rs17782313 in mc4r gene and rs2282679 in VDBP gene on the TG-HDL ratio and HOMA-IR through pregnancy

Background Maternal adaptations during pregnancy are needed to support the adequate growth and development of the fetus, delivery and lactation. They generate an insulin resistance status and altered lipid metabolism, which can evolve into an imbalance that may precede diabetes and cardiovascular diseases. These patterns of alterations are a result of different interaction amongst genes and environmental factors.