African-Caribbean ethnicity and HbA1c variability are associated with rapid non-linear renal function decline in patients with type 2 diabetes who reach end-stage renal disease

Abstract In a study of eGFR trajectories in 398 T2DM patients, a non-linear eGFR trajectory was observed in 59% of the 71 patients who reached end-stage renal disease (ESRD). African-Caribbean ethnicity and glycaemic variability are independently associated with distinct non-linear eGFR trajectories that result in fast progression to ESRD.