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Darrin Stuart

Novartis

60

Papers

1977

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RAF-mutant melanomas differentially depend on ERK2 over ERK1 to support aberrant MAPK pathway activation and cell proliferation.

2021 Molecular Cancer Research
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LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors.

2020 Clinical Cancer Research
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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

2019 Journal of Medicinal Chemistry
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Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma

2019 Molecular Cancer Research
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Tumor intrinsic efficacy by SHP2 and RTK inhibitors in KRAS mutant cancers.

2019 Molecular Cancer Therapeutics
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Distinct transcriptional programming drive response to MAPK inhibition in BRAFV600 mutant melanoma patient derived xenografts

2019 Molecular Cancer Therapeutics
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Abstract LB-114: RAF inhibitor LXH254 effectively inhibits B-and-CRAF, but not ARAF

2019 Cancer Research
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Abstract 4769: Gene expression profiling of response to short- and long-term treatment of LSZ102 in MCF7 cells

2019 Cancer Research
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In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

2019 bioRxiv
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Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

2018 Cancer Research
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