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Jing Yuan

Pfizer
Novartis

40

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1583

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A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing

2020 bioRxiv
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LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors.

2020 Clinical Cancer Research
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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

2019 Journal of Medicinal Chemistry
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Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

2017 Journal of Medicinal Chemistry
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Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers

2017 Cancer Research
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Abstract 2740: Mechanistic basis of Palbociclib combinatorial activity in ER+ breast cancer and non-breast indications

2016 Cancer Research
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Abstract P3-06-01: Mechanisms of resistance to CDK4/6 inhibition in ER+ breast cancer

2016 Cancer Research
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Abstract 5062: Ovarian cancer cells induce the microenvironment changes and subsequently promote disease propagation and dissemination through epithelial-mesenchymal transition and enrichment of tumorigenic cells

2015 Cancer Research
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Abstract A42: Palbociclib potentiates nab-paclitaxel efficacy in pancreatic ductal adenocarcinoma

2015 Molecular Cancer Therapeutics
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Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097

2015 Molecular Cancer Therapeutics
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Citations (40)