Abstract TP61: Determinants of CT Perfusion Misrepresentation of Ischemic Core in Endovascular Stroke Therapy

Introduction: CT Perfusion (CTP) has become an essential tool in determining candidates for endovascular stroke therapy (EST), particularly in later time windows. However, the reliability of CTP to define infarct core may vary based on time of onset and other clinical factors. Methods: From our prospective institutional registry, we identified patients between 1/2014 - 3/2017 that underwent EST with successful reperfusion (TICI 2b/3), pre-procedure CTP and 24hr MRI. Source CTP data were analyzed using OleaSphere (La Ciotat, France) rCBF 10cc disparity between CTP core and 24hr DWI. Multivariate logistic regression assessed factors associated with MM (p<0.05 significant, p<0.10 trend). Results: Among 109 patients (60 with RAPID) studied, mean age was 63±15, median NIHSS 19[15.5-22], median ASPECTS 8 [7-10], and occlusion location ICA in 19 (17%) and M1 in 90 (83%). CTA collateral grades were 0-2a in 70 (64.2%) and 2b/3 in 36 (35.8%). ...