Influencing factors for cerebral microbleeds in patients with acute ischemic stroke

Objective To investigate the relationship between cerebral microbleeds(CMB),cardiovascular risk factors,and plasma fibrinogen in patients with acute ischernic stroke.Methods Sixtyeight patients with acute ischemic stroke from June 2008 to March 2009 were enroued prospectively.All patients received cranial magnetic resonance imaging at the first week,and T2~*-weighted gradient echo MRI sequence was performed to detect CMB.Plasma fibrinogen,uric acid levels and other biochemical parameters were measured on the next day of admission.All data were selected from Nanjing Stroke Registry Program.Results Among a total 68 patients,29(43%)patients had 109 lesions of cerebral microbleeds on gradient-echo MRI.Age,hypertension,fibrinogen and uric acid were significantly associated with the presence of CMB(P=0.004,0.024,0.020,0.027 respectively).Through a logistic regression analysis,age,hypertension and plasma fibrinogen were significantly associated with the presence of cerebral microbleeds[(P=0.02,OR=1.10,95 % CI 1.02 to 1.19;P=0.003,OR=9.35,95 % CI2.17 to 40.23;P=0.019,OR=1.01,95% CI1.00 to 1.02].Conclusion There is a high prevalence of CMB in patients with acute ischemic stroke.And it has a strong relationship with high plasma fibrinogen. Key words: Cerebral infarction; Fibrinogen; Hypertension; Cerebral microbleeds