Quantification of Left Ventricular Function with Thallium-201 and Technetium-99m-Sestamibi

Myocardial gated SPECT with 99mTc-sestamibihas been used to quantify left ventricular function. The purpose of this study was to determine if myocardial gated SPECT with 201TIwas possible and reliable to quantify left ventricular function. Methods: One hundred and four patients referred for a myocardial perfusion study were included. Myocardial gated SPECT acquisition was performed 15 min after the intravenous injection of 111 MBq (3 mCi) 201TIand at 1 hr postinjection of 925 MBq (25 mCi) ""Tc-sestamibi. A commer cially available automated myocardial gated SPECT processing software was used. Parameters evaluated were left ventricular ejec tion fractions (LVEF),end-diastolic volumes (EDV),end-systolic vol umes (ESV)and stroke volumes (SV). Results: The correlation be tween gated SPECT with 201TIand gated SPECT with ""Tcsestamibi was: r = 0.93 for LVEF,0.92 for EDV,0.96 for ESVand 0.68 for SV. Conclusion: Myocardial gated SPECT quantification of left ventricular function with 201T1 was possible and as reliable as gated SPECT with ""Tc-sestamibi. There was excellent correlation be tween gated SPECT with 201T1 and gated SPECT with "Tc-sestamibi. In addition to assessment of myocardial perfusion, myocardial function and viability can be quantified in a single gated 201TIstudy.