GP297 Evaluation of an early biochemistry marker of renal injury in obese children

Background The obesity is the most prevalent nutrition-related disorder in children and becomes a major health issue worldwide. An increased risk of renal injury in children has been associated with overweight and obesity. Objective To investigate the renal tubular function and early kidney injury in obese pediatric patiens. Methods The 57 (M:F=32:25) patients from University Children Hopital-Skopje have been investigated from December 2016 y till March 2019y. They have been diveded in 2 groups: a group of thirty seven obese (body mass index (BMI) z-score ≥2) patiens (M:F=20:17), and the control group of twenty non-obese children (M:F=12:8) with BMI z-score ≤2. The blood samples have been collected in the morning, after an overnight (at least 8 h), for measurements of complete blood count and biochemical parameters, including serum concentrations of creatinine, fasting glucose and lipid profile. The spot urine samples have been collected to assess NGAL levels as renal injury marker, and have been performed by Chemiflex (Abbott Architect I 1000 sr). Results The serum concentrations of all examined parameters have been increased in the obese group, while only the HDL cholesterol levels have been decreased, compared to those in non-obese controls. The levels of analysed urine NGAL concentrations have been elevated in the obese group of children. Conclusions Herein, in our study, we present the increased concentrations of NGAL in urine in the obese children compared to non-obese group of patients. We may confirm that urinary NGAL is useful and an early reliable marker for detection of renal damage in the obese pediatric patiens.