Antioxidant Status in Vascular Dementia

Vascular dementia (VaD) is the second most common form of dementia. Different studies have indicated that patients with VaD have increased levels of local and systemic oxidative stress markers. Furthermore, in vivo and clinical experiments have demonstrated that the administration of antioxidants via foods and/or supplementation therapies significantly reduces the pathological features of VaD, including cognitive decline. Here, we provide a survey of studies about the role of oxidative stress and antioxidants in VaD pathogenesis. Moreover, we suggest the potential approach that caregivers might use to verify the effectiveness of antioxidants to prevent VaD or treat VaD patients.