Abstract T MP77: Incidence of Neurofluctuation in Patients with Subcortical Ischemic Stroke - Results from a Prospective Cohort Study

Subcortical strokes (SCS) are associated with stroke progression. The primary objective was to assess the incidences of neurological deterioration and its spontaneous reversal in SCS patients. We also estimated the risk of poor outcome associated with deterioration. Methodology: A prospective cohort of SCS patients was enrolled based on clinical exam and imaging studies, and was followed through the course of hospitalization. NIH stroke scale (NIHSS) assessments were performed daily and whenever symptoms worsened (increase of ≥ 1 in motor scale). Modified Rankin Scale (mRS) score at discharge was used to assess outcomes. Patients received standard of care stroke therapy including IV t-PA as per AHA guidelines, and episodes of deterioration were managed conservatively. The Anderson Gill Cox proportional hazard model was used to analyze factors associated with time to deterioration and spontaneous reversal. Log binomial regression was performed for estimation of risk of poor outcome. Results: The cumulative...