[Serum levels of sVCAM-1, IL-18 and VEGF in patients with aplastic anemia and their clinical significance].

This study was purposed to investigate the serum levels of soluble intracellular adhesion molecule(sVCAM-1),interleukin 18(IL-18) and vascular endothelial growth factor(VEGF) in patients with aplastic anemia(AA) and their clinical significance.Enzyme linked immunosorbent assay(ELISA) was used to detect sVCAM-1,IL-18 and VEGF in serums of 30 patients with AA and 25 normal controls.The results showed that the serum levels of sVCAM-1 and IL-18 in patients with AA [(839.08±173.97)ng/ml,(380.35±47.76)pg/ml ] were significantly higher than those in normal controls [(538.16±91.21)ng/ml,(256.39±59.52)pg/ml ](p0.01;p0.01).The levels of sVCAM-1 and IL-18 in severe AA patients [(969.94±182.54)ng/ml,(388.96±46.06)pg/ml] were higher than those in chronic AA patients [(709.26±165.32)ng/ml,IL-18(352.21±47.08)pg/ml](p0.01;p0.05),but the level of VEGF in AA patients[(69.63±27.42) pg/ml] was lower than that in the normal controls[(125.62±32.15)pg/ml](p0.01)].The level of VEGF in severe AA patients[(51.30±29.86) pg/ml ]was significantly lower than that in chronic AA patients[(80.02±25.14) pg/ml](p0.01).The levels of sVCAM-1 and IL-18 in AA patients after treatment were lower than those before treatment(p0.01;p0.05),but the level of VEGF after treatment was significantly higher than that before treatment(p0.05).It is concluded that the high levels of sVCAM-1,IL-18 and low level of VEGF in serum may be involved in the pathogenesis and progress of AA.