In patients with stable coronary heart disease low-density lipoprotein-cholesterol levels <70 mg/dL and glycosylated hemoglobinA1c< 7% are associated with lower major cardiovascular events

Abstract Background In patients with stable coronary heart disease (CHD) it is not known as to whether achievement of SOC targets in addition to evidence-based medicine (EBM) is associated with lower major adverse cardiovascular events (MACE): cardiovascular death, myocardial infarction, and stroke. Methods EBM use was recommended in the STabilisation of Atherosclerotic plaque By Initiation of darapLadIb TherapY (STABILITY) trial. SOC targets were blood pressure (BP) Results In 13,623 patients, 1 year landmark analysis assessed the association between EBM, SOC targets, and MACE during follow-up of 2.7 years (median) after adjustment in a Cox proportional hazards model. At 1 year, aspirin was prescribed in 92.5% of patients, statins in 97.2%, beta-blockers in 79.0% and angiotensin converting enzyme inhibitors / angiotensin-II receptor blockers in 76.9%. MACE was lower with LDL-C  Conclusion MACE was lower with LDL-C