4CPS-186 Vision-related quality of life in patients diagnosed with retinal pathology

Background The retinal pathologies, main causes of blindness, produce a negative impact on patients’ vision-related quality of life (vrQoL). Purpose To describe the baseline vrQoL in patients diagnosed with neovascular age-related macular degeneration (nAMD), diabetic macular oedema (DME) or branch/central retinal vein occlusion (B/CRVO). Material and methods Observational, prospective study, from February 2014 to December 2016. Patients diagnosed with nAMD, DME or B/CRVO, who began with intravitreal ranibizumab and no treatment before, were included. The study was approved by the local Ethics Committee. The National Eye Institute Visual Function Questionnaire (NEIVFQ-25) 1 was obtained by interviewer-administered format by previous informed consent for each patient. The NEIVFQ-25 is a 25-question instrument with 12 subscales: general health, general vision, near vision, distance vision, driving, peripheral vision, colour vision, ocular pain, role limitations, dependency, social function and mental health. The answer to each question is converted to a 100-point scale, where 0 represents the worst score and 100 the maximum. Items are averaged together to produce the scale score. Collected data were sex, age, retinal pathology, affected eye, baseline best-corrected visual acuity (BCVA), other ocular and systemic pathologies and glycated haemoglobin (HbA1c) level in diabetic patients. The statistical analysis was performed using SPSS version 20.0. Results Ninety-three patients were recruited (59% females, 41% males). The mean age was 74.1±11.1 years and the mean BCVA in the best eye was 0.8±0.7 logMAR. Baseline characteristics: Retinal pathology: nAMD 67% (63/93); DME 21.3% (20/93), BRVO 8 5% (8/93); CRVO 3.2% (3/93). Affected eye: right eye 43% (40/93), left eye 31.2% (29/93), bilateral 25.8% (24/93). Ocular pathologies: without cataract 48.4% (45/93); cataract without surgery 18.3% (17/93); with surgery (pseudoaphakia) 33.3% (31/93). glaucoma 7.5% (7/93), vitrectomy 3.2% (3/93). Systemic comorbidities: cardiovascular disease 31.2% (29/93); hypertension 66 7% (62/93), diabetes mellitus 32.3% (30/93); hypercholesterolaemia 14% (13/93); previous stroke 1.1% (1/93). Mean HbA1c: 7.9%±1.4. The baseline NEIVFQ-25 outcomes were: Overall composite score: 73.57±16.33. General health: 39.52±20.30. General vision: 56.88±15.03. Near vision: 63.80±22.61. Distance vision: 71.44±22.55. Driving: 68.18±39.55. Peripheral vision: 76.61±26.27. Colour vision: 94.23±13.98. Ocular pain: 78.09±24.98. Role limitations: 64.92±29.96. Dependency: 83.87±23.60. Social function: 85.05±20.27. Mental health: 66.33±21.43. Conclusion General health, general vision, near vision, mental health and role limitations are several areas affected in patients with retinal pathologies, however, social function and dependency are the lowest affected. Reference and/or Acknowledgements 1. Mangione CM. The National Eye Institute 25-Item Visual Function Questionnarie (NEIVFQ-25) scoring algorithm –August 2000. No conflict of interest