Abstract TP414: Early and Delayed Onset Poststroke Depression

Background and aim: We aimed to investigate the predictors for early (3-month) and delayed (3-year) depression after stroke. Methods: Stroke or transient ischemic attack (TIA) subjects (n=1023) were recruited from the Chinese University of Hong Kong - STroke Registry Investigating cognitive DEcline (CU-STRIDE). Clinical factors, drug use and neuroimaging markers of small vessel diseases (SVD) were collected at baseline. Geriatric depressive score (GDS) 15-items (≥ 6) was used to ascertain the presence of depression. Logistic regression was used to explore risk factors for presence of depression at 3-month and delayed-onset depression at 3-year, respectively. Results: A total of 394 (38.5%) patients had depression at 3-month after stroke/TIA, leaving 629 depression-free subjects. Among these 629 subjects, 350 received re-assessment of GDS at 3-year, and 49 (14%) developed depression. At 3-month, National Institute of Health Stroke Scale (NIHSS) score (OR=1.09, 95% CI: 1.04-1.14, p<0.001), Montreal Cognitiv...