Association between glycemic variability and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome during 30-day follow-up

Abstract Background We explored the association between glycemic variability and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome (ACS) during 30-day follow-up. Methods From May 2013 to April 2015, a total of 864 patients with ACS were divided to high glycemic variability group (H group) (n = 285) and low glycemic variability group (L group) (n = 579). The primary end point was a 30-day incidence of MACCE. Secondary end points were the incidence of atrial fibrillation (AF) during hospitalization and length of hospital stay. Results The primary end point occurred in 15.2% of patients in H group and in 9.7% in L group (p = 0.03). The incidence of AF during hospitalization was 14.5% in H group and 8.9% in L group (p = 0.02). Compared with the L group, the H group extended the length of hospital stay. Multivariable analysis suggested that high glycemic variability conferred a 57% risk increment of 30-day MACCE (odds ratio 1.97, 95% confidence interval 1.32–6.86; p = 0.02). Conclusion The trial shows that higher blood glucose variability was correlated with higher incidence of MACCE, AF and longer length of stay.