Diabetes Mellitus, Inflammation, Obesity: Proposed Treatment Pathways for Current and Future Therapies:

ObjectiveTo review the pathophysiology, pharmacology, and current or future therapies under study for use in treating diabetes mellitus, inflammation associated with diabetes mellitus, and/or obesity related to diabetes mellitus, through 1 of 4 investigational pathways: adiponectin, ghrelin, resveratrol, or leptin.Data sourcesA literature search using MEDLINE (1966–December 12, 2009), PubMed (1950–December 12, 2009), Science Direct (1994–December 12, 2009), and International Pharmaceutical Abstracts (1970–December 12, 2009) was performed using the terms adiponectin, ghrelin, resveratrol, leptin, inflammation, obesity, and diabetes mellitus. English-language, original research, and review articles were examined, and citations from these articles were assessed as well.Study selection and data extractionClinical studies and in vitro studies were included in addition to any Phase 1, 2, or 3 clinical trials.Data synthesisMechanistic pathways regarding adiponectin, ghrelin, resveratrol, and leptin are of intere...