Antihypertensive Medications and Depression

The association between antihypertensive medications and depression has been recognised for over 40 years. More recently, our understanding of the role of neurotrnsmitters in the aetiology of depression has helped us understand how antihypertensive drugs cause depression. Biogenic amine depletion is now believed to underlie the organic nature of depression, and many of the drugs used to treat hypertension interfere with this system