Chapter 1 – Acute Ischemic Stroke

Major progress has occurred in the therapy of ischemic stroke, predominantly in the field of reperfusion with intravenous thrombolysis and endovascular thrombectomy. Challenges remain in implementation with underutilization of thrombolysis and rapidly evolving systems for delivery of endovascular thrombectomy, which brings new resource challenges. Multiple trials of putative neuroprotective compounds have been disappointing but there is new enthusiasm in the era of highly effective endovascular reperfusion and more rigorous preclinical evaluation.