Immunosuppressive Drugs in Paediatric Liver Transplantation

Orthotopic liver transplantation is established treatment for children with acute and chronic liver failure. Despite advances in pre- and postoperative management, innovative surgical techniques and new immunosuppressive drugs, acute and chronic rejection remains a problem. In addition, well established adverse effects of commonly used immunosuppressive drugs are no longer acceptable. More potent, but less toxic, immunosuppressive agents have been developed and some novel compounds are now entering routine practice.