AB0074 Interleukin-23 in Serum of Patients with Antineutrophil Cytoplasmic Antibody- Associated Systemic Vasculitis: Table 1.

Background There is probably a systemic shift of cytokine production in patients with antineutrophil cytoplasmic antibody (ANCA)- associated systemic vasculitis (AAV) toward the Th17 cytokine response. We investigated whether interleukin-23 (IL-23), Th17- related cytokine, have any correlations with disease activity, clinical manifestations and treatment in AAV. Objectives To analyse the concentration of interleukin-23 (IL-23) in serum of AAV patients, compared with healthy controls (HC). Methods An enzyme- linked immunosorbent assay (ELISA) was used to analyse the serum concentration of IL-23 in 40 patients with AAV (median age 44 yrs (20- 65); F:M=1,11) and 8 HC (median age 47 yrs (21- 66); F:M=1,67). 23 patients were classified as granulomatosis with polyangiitis (GPA), 14- microscopic polyangiitis (MPA), and 3- eosinophilic granulomatosis with polyangiitis (EGPA). 26 patients were examined in active phase, 28- in remission (in 22/28 remission was induced by rituximab). The correlations between the levels of IL-23 and disease activity, clinical parameters were analysed. Results The levels of IL-23 increased significantly in the serum of active PR3-ANCA patients before treatment compared with HC (median 41.9 pg/ ml and 13.1 pg/ ml, respectively, p Conclusions There is a prospect further study of IL-23 and functionally similar cytokines in the pathogenesis of AAV. Disclosure of Interest None declared