The Influence of Carotid Plaque Morphology on the Development of Cerebral Symptoms

Background: Large randomized trials such as the European Carotid Surgery Trial (ECST) and North American Symptomatic Carotid Endarterectomy Trial (NASCET) have defined a role for carotid endarterectomy in symptomatic patients with severe carotid artery stenosis. Data from the same trials also shows that a subgroup of patients with less severe stenosis with a higher risk of stroke might benefit form carotid endarterectomy. In recent years, it has become apparent that besides the degree of stenosis, the morphology of the plaque itself plays a significant role in its potential for development of symptoms, and noninvasive methods of assessing plaque morphology are currently being developed. This paper reviews the literature regarding the relationship between carotid plaque morphology and the potential for development of clinical symptoms.Methods: A Medline search and a meta-analysis of the literature was carried out. Intraplaque hemorrhage and plaque ulceration were both found to be associated with a higher r...