Concordance of Estimated Glomerular Filtration Rates Using Cockcroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology in Renal Transplant Recipients

Abstract Introduction Various equations have been used to estimate the glomerular filtration rate (GFR) in renal patients, including kidney transplant recipients. Controversy exists concerning which equation is more precise to determine kidney failure. Aim The aim of this study was to analyze the concordance (bias, variability, and exactness) of GFR estimated by the Modification of Diet in Renal Disease (MDRD4) and the Chronic Kidney Disease Epidemiology (CKD-EPI) equations using the Cockcroft-Gault (CG) method as the reference. Material and Methods This observational, cross-sectional study included 153 clinically stable patients who underwent kidney transplantation between 2007 and 2009. The GFR was estimated at 12 months after the transplantation using the MDRD and CKP-EPI formula, using CG as the reference. Results The mean GFR for the various methods was as follows: CG = 65.6 ± 23.3 mL/min/1.73 m 2 , MDRD4 = 54.9 ± 19.3 mL/min/1.73 m 2 , and CKD-EPI = 55.8 ± 19.6 mL/min/1.73 m 2 . Good correlations were found between CG-MDRD4 ( r = 0.84; P r = 0.87; P r = 0.98; P 2 ( P = .006), a variability (percent difference) of 14.5 ± 15.4% versus 13.6 ± 14.5% ( P = .031), and an exactness (P30) of 81.7% versus 86.9% ( P 60 mL/min/1.73 m 2 the exactness was 75.3% versus 83.5% ( P 2 it was 89.7% versus 91.2% ( P Conclusions In our population the CKD-EPI method most approached the CG values, particularly when the GFR was >60 mL/min/1.73 m 2 .