The Association between Osteocalcin and Type II Diabetes in Egyptian Male Patients

: Type 2 Diabetes Mellitus (T2DM) is a growing concern worldwide. It is multifactorial and if it is not managed properly, complications will appear both in short-term and long-term incidence. Recent studies have demonstrated a link between bone and glucose metabolism. Serum osteocalcin (OC) level and percentage of glycated haemoglobin (HbA 1c ) were assessed in 60 Egyptian male adults. Serum OC levels were significantly decreased in newly diagnosed T2DM patients compared with nondiabetic subjects (p<0.001). Percentage of HbA 1c was higher in the newly T2DM patients as compared to the control subjects (p<0.001). In partial correlation analysis adjusted for age, serum OC level was inversely correlated with HbA 1c (r = - 0.068, p < 0.05). Our data suggest that low serum OC level might have a role in the pathogenesis of impaired glucose metabolism in Egyptian T2DM male patients.