Abstract W P125: Glycemic Variability Should Be Associated with the Ischemic Volume Expansion and Neurological Deterioration in Acute Stroke

Background and Purpose: Several studies suggested that hyperglycemia on admission worsen the prognosis of acute stroke patients. However, it is not clear that glycemic variability in acute stroke is associated with neurological deterioration and infarct volume expansion. The purpose of this study was to clarity above issue using continuous glucose monitoring device (CGMS). Methods: Consecutive acute stroke patients with the internal carotid artery(ICA) or middle cerebral artery(MCA) occlusion within 24 hours of stroke onset were prospectively studied. We evaluated glucose values during 72 hours after stroke onset using CGMS. All patients were classified into following three groups. Persisting hyperglycemia (PH) group had persisting hyperglycemia as glucose level above 180mg/dl, persisting normoglycemia (PN) group had persisting normoglycemia as glucose level 70mg/dl to 140mg/dl and the glucose variability (GV) group had glycemic variability as glucose level 70mg/dl to 400mg/dl during 72 hours monitoring. ...