Comparisons of the corneal biomechanics between low and high myopic eyes –a meta-analysis

Abstract Purpose To compare the corneal biomechanical difference between the low myopic eyes and high myopic eyes. Design Systematic review and meta-analysis. Methods Data sources, including PubMed, Medline, EMBASE, Web of Science, and Chinese databases including Wanfang, and China National Knowledge Infrastructure were searched to find the relevant studies. Primary outcome were corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), goldmann-correlated intraocular pressure (IOPg), and central corneal thickness (CCT) in high myopic eyes and low myopic eyes. Results Eleven studies were enrolled in this study. The CH and CRF were significant higher in the low myopic eyes. The mean difference of CH was 0.73 mmHg, 95% confidence interval (CI) [0.53 to 0.93], P Conclusion Corneal biomechanics are different in the high myopic eyes. The low CH, CRF, high IOPcc and IOPg are suggested to be associated factors for high myopia. Future studies are needed to investigate the underlying corneal structure difference that cause the low CH and CRF value in the high myopic eyes.