Formation of liquid crystalline phases in aqueous suspensions of platelet-like tripalmitin nanoparticles

Suspensions of platelet-like shaped tripalmitin nanocrystals stabilized by the pure lecithin DLPC and the lecithin blend S100, respectively, have been studied by small-angle x-ray scattering (SAXS) and optical observation of their birefringence at different tripalmitin (PPP) concentrations φPPP. It could be demonstrated that the platelets of these potential drug delivery systems start to form a liquid crystalline phase already at pharmaceutically relevant concentrations φPPP of less than 10 wt. %. The details of this liquid crystalline phase are described here for the first time. As in a previous study [A. Illing et al., Pharm. Res. 21, 592 (2004)] some platelets are found to self-assemble into lamellar stacks above a critical tripalmitin concentration φPPPst of 4  wt. %. In this study another critical concentration φPPPlc≈7 wt. % for DLPC and φPPPlc≈9  wt. % for S100 stabilized dispersions, respectively, has been observed. φPPPlc describes the transition from a phase of randomly oriented stacked lamellae...