Abstract 113: CT Perfusion Mismatch Identifies More Thrombectomy Patients Than Clinical Core Mismatch

Background: Following DAWN and DEFUSE 3, optimal imaging selection of large vessel ischemic stroke patients for thrombectomy >6h is important. We hypothesized that perfusion mismatch used in EXTEND-IA and DEFUSE 3 would identify more patients eligible for thrombectomy than clinical-core mismatch used in DAWN. Methods: Prospectively collected data were analyzed for acute ischemic stroke patients aged>18 with pre-treatment whole brain CT perfusion from 2012-2017 at a comprehensive stroke center. CTP was omitted >6h in patients with extensive CT hypodensity. We compared the proportion of patients with anterior circulation large vessel occlusion (ICA, M1 and tandem occlusions) who fulfilled criteria for DAWN (clinical-core mismatch: age 80 & NIHSS>10 with 1.8, mismatch>15mL, core 5) and EXTEND-IA (mismatch ratio>1.2, mismatch>10mL, core<70mL, no age or NIHSS limits). Pre-morbid funct...