Study on the relationship between poor sleep quality and stoke

Objective To explore the relationship between poor sleep quality and stoke. Methods A total of 738 stroke patients in Xuzhou city in 2013 were selected as the case group and age-and sex-matched healthy non-stroke subjects(n=738)as control group.The writer-designed general situation questionnaire and the Pittsburgh Sleep Quality Index(PSQI)analyses were conducted for a face-to-face investigation. Results No significant difference in mean age(66.1±10.9 and 65.8±10.6, t=0.60, P=0.58)and in sex(50% vs.50%)was found between two groups.There were statistically significant differences between case and control groups in baseline values of BMI(t=2.40, P=0.02), histories of hypertension(χ2=174.30, P=0.00), diabetes mellitus(χ2=27.20, P=0.00), coronary heart disease(χ2=115.60, P=0.00), smoking(χ2=6.10, P=0.01), drinking(χ2=7.30, P=0.01)and living stress(χ2=11.40, P=0.01). The PSQI sub-scores and PSQI total scores were higher in case group than in control group.The rate of poor sleep quality was higher in case group(279 cases, 37.8%)than in control group(136 cases, 18.4%)(χ2=6.10, P=0.01). Multivariate logistic analysis showed that, after adjusting for confounding factors of BMI, histories of hypertension, diabetes, coronary heart disease.smoking, drinking and living stress, the poor sleep quality in total male plus female was independent predictor variables for stroke[odds ratio(95%CI)of 2.3(1.8-3.0)], no matter their sex, with odds ratio(95%CI)in male(2.5, 1.7-3.7)or in female(2.2, 1.5-3.2), respectively, but there was no significance difference in the odds ratio between male and female in case group(χ2=0.04, P=0.85). The risk stroke was 2.3 folds higher in poor sleep quality versus control in male plus female, with pure male or female of 2.5 or 2.2 folds.There was no significance difference between male and female in case group versus.the control(χ2=0.04, P=0.85). Conclusions Poor sleep quality is associated with the occurrence of stroke and may be a risk factor for stroke. Key words: Stroke; Sleep quality; Case-control study