Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery

Tammy W. Shen,Catherine A. Fromen,Marc P. Kai,J. Christopher Luft,Tojan B. Rahhal,Gregory R. Robbins,Joseph M. DeSimone

Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery

2015

Tammy W. Shen
Catherine A. Fromen
Marc P. Kai
J. Christopher Luft
Tojan B. Rahhal
Gregory R. Robbins
Joseph M. DeSimone

Purpose We evaluated the role of a poly(ethylene glycol) (PEG) surface coating to increase residence times and alter the cellular fate of nano- and microparticles delivered to the lung.

Keywords:

PEGylation
Ethylene glycol
Nanoparticle
Cell
Nanotechnology
Microparticle
Organic chemistry
Chemistry
Chromatography
Biophysics
cell specific
surface coating
Biochemistry
PEG ratio
Lung

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