Association between Rosacea and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.

Abstract: Background Rosacea is recognized as a chronic inflammatory cutaneous disorder associated with multiple systemic illnesses. However, the association between rosacea and cardiometabolic disease (CMD) remains controversial. Objective To evaluate the association between rosacea and CMD by a systematic review and meta-analysis. Methods A comprehensive search of studies published before Oct 16, 2019 was performed in databases of PUBMED, EMBASE, Cochrane Library and Web of Science. The pooled risk ratios (RRs) or standardized mean differences (SMDs) were calculated. Results Thirteen studies were included, representing 50,442 patients with rosacea. Rosacea cases had higher prevalence of dyslipidemia, higher prevalence of hypertension, higher total cholesterol (TC), higher low-density lipoprotein (LDL), higher triglycerides (TG), higher systolic blood pressure, higher diastolic blood pressure and higher fasting blood glucose (FBG). Rosacea was not associated with ischemic heart disease (IHD), stroke, diabetes and high-density lipoprotein (HDL). Limitations No subgroup analysis could be performed according to the subtypes and severity of rosacea. Conclusion Rosacea showed a correlation with hypertension and dyslipidemia, but not with IHD, stroke, nor diabetes. We advocate screening for CMD indicators among rosacea patients, which may be helpful for diagnosis and appropriate treatment at an early stage of disease.