Resolution of Late Steroid-Responsive Nephrotic Syndrome in a Patient with Alport Syndrome Treated with Atorvastatin
2015
Experimental and
clinical studies have pointed out the lipid-induced renal damage, and statins
may have pleiotropic effects on renoprotection. We reported a girl with
X-linked Alport syndrome whose late steroid-responsive nephrotic syndrome (NS)
was resolved by atorvastatin. She had been in a nephrotic condition despite of
prednisone therapy 60 mg/day for 8 weeks. Renal biopsy dispicted extreme foamy
appearance of tubular epithelial cells with detachment led to luminal
obliteration. Atorvastatin was started on the ninth week of prednisone therapy
due to severe hypercholesterolemia. Partial remission of NS was dramatically
achieved with unchanged dosage of prednisone at the end of the twelfth week.
Our case provides a pathology-based evidence to support the use of statins in
profoundly hyperlipidemic patients with NS. In patients with NS and profound
hyperlipidemia, early initiation of statin therapy is required in combination
with immunosuppressive therapy.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
15
References
0
Citations
NaN
KQI