Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome.
2016
The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and large,
more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting. Studies are not currently
available on the association between MPV and stroke recovery after neurorehabilitation. The relationship between MPV
and clinical and functional outcome measures was assessed in twenty-four patients in the acute phase of first-ever
ischemic stroke, and before and after 8-week intensive multifunctional neurorehabilitation. Neurorehabilitation was associated
with improved scores of the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS),
and the modified PULSES profile (mPULSES). When compared with apparently healthy subjects, higher MPV values
were observed in stroke patients 24 hours after stroke and before neurorehabilitative treatment started not later than 14
days after stroke. Decreased MPV values were found after neurorehabilitation, even if the absolute values were still higher
than those detected in control subjects. No correlation was observed between MPV values and scores of the NIHSS and
mRS scales evaluated in stroke acute phase. No correlation was also observed before and after neurorehabilitative treatment
between MPV and NIHSS, mRS and mPULSES scores. Our data provide evidence of the effectiveness of neurorehabilitation
on modulating MPV values and support the hypothesis that high MPV could represent an expression of proinflammatory
condition of the stroke patients, realistically pre-existent to acute ischemic event, than a marker of neurologic
deficit and disability or of stroke recovery including motor performance and functional independence.
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