Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats

Pei-Jun Li,Ying Qiang Guo,Pei-yan Ding,Ruo-bing Liu,Fei Deng,Xiao Xue-feng,Wen-Jun Yan

Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats

2019

Pei-Jun Li
Ying Qiang Guo
Pei-yan Ding
Ruo-bing Liu
Fei Deng
Xiao Xue-feng
Wen-Jun Yan

ABSTRACTObjectives: To investigate the effect of purmorphamine (PUR), a Shh co-receptor Smoothened (Smo) agonist, on postoperative cognitive dysfunction (POCD) rat models.Methods: Eighteen-month-ol...

Keywords:

Anesthesia
Diabetes mellitus
Medicine
Autophagy
Agonist
Neuroprotection
Dentate gyrus
Postoperative cognitive dysfunction
Smoothened Receptor
Pharmacology
Hippocampus
Smoothened
Purmorphamine

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