Response to Letter Regarding Article, “Hypothermia in Comatose Survivors From Out-of-Hospital Cardiac Arrest: Pilot Trial Comparing 2 Levels of Target Temperature”

We thank Kagawa et al for their comments and appreciate their interest in our work.1 We agree with them that there are many possible factors that could influence the results of our pilot study. All of these factors could not be controlled in our study. Kagawa et al, based on the results of their retrospective study,2 consider that the relative risk of favorable neurological outcomes is 0.90 with a time interval of 1 minute from collapse to return of …