Evaluation of conformity of a first prescription of lipid-based formulation of amphotericin B in a university-teaching pediatric hospital.

OBJECTIVE Invasive fungal infections are an important cause of morbidity and mortality in immunodeficient children. Amphotericin B is an important therapeutic agent for the treatment of invasive fungal infections but is associated with significant toxicities and high acquisition costs. The purpose of this study was to evaluate physician adherence to a local guideline for the use of lipid-based amphotericin B. METHODS The study was approved through Pharmacology & Therapeutics (PT recommended drug of choice—Abelcet; accepted indications; and presence of underlying conditions). RESULTS A total of 109 orders for 70...