[Advances in the role of autoantibodies in diabetic nephropathy: Review].

: Diabetic nephropathy (DN) is the most common cause of global end-stage renal disease (ESRD) and is one of the leading causes of mortality in patients with type 1 and type 2 diabetes. Recent studies have found that autoimmunity is closely related to the occurrence and development of DN, especially the autoantibodies which play a crucial role in the pathogenesis of DN. Currently, autoantibodies found in the serum of DN patients mainly include G-protein coupled receptor autoantibodies, pancreatic autoantibodies and autoantibodies related to endothelial cell damage. In the special environment of diabetes, high glucose (HG) can stimulate the production of a variety of autoantibodies, which can mediate the damage of renal function via different mechanisms and affect the progression of DN. Therefore, it is important to explore the role of autoantibodies in the pathogenesis of DN.