Gender Difference in Stroke: Are They Different in India? (P1.261)

Objective: We aimed to explore the gender differences in age, incidence, type, risk factors and outcome of stroke in Ludhiana city population based stroke registry. Background: Men and women follow a different profile of vascular risk factors; have a different response to medical treatment and therapeutic interventions, as well as post-stroke disability and care. However data is scarce regarding gender differences in stroke from low and middle income countries. Methods: All first ever stroke patients (≥18 years) were included from January 2011 to December 2012 from the Ludhiana population based stroke registry. Data was collected using WHO STEPS approach. Stroke deaths were obtained from Municipal Corporation. The outcome was assessed using modified Rankin scale (≤ 2: good outcome) at 28 days. The statistical measures calculated were: descriptive statistics, independent t-test and chi square test. Statistical analysis was performed using SPSS version 21 (Armonk, NY: IBM Corp.). Results: Out of 2811 patients enrolled, 1073 (38[percnt]) were women. The mean age was (men 59±15 years versus women 60±15 years; p=0.03). The incidence rate was higher in men (men 181/100,000; 95[percnt] confidence interval (CI): 170-192 versus women 125/100,000; 95[percnt] CI: 115-135; p=0.05). Hypertension (83.6[percnt] versus 77.5[percnt]; p=0.002), hyperlipidemia (20.3[percnt] versus 16.5[percnt]; p=0.04) and rheumatic heart disease (5.2[percnt] versus 2.6[percnt]; p=0.004) were common in women, whereas alcohol intake (24[percnt] versus 0.6[percnt]; p<0.0001), drug addiction (9.5[percnt] versus 2.2[percnt]; p< 0.0001) and smoking (11.4[percnt] versus 0.9[percnt]; p<0.0001) were higher in men. Men were more likely to have hemorrhagic stroke (32.3[percnt] versus 26.1[percnt]; p<0.001). There was no difference in stroke outcome (men, 52.3[percnt] versus women, 49.6[percnt]; p=0.20). Conclusion: The incidence rate was higher in men as compared to women. There were differences in risk factors and stroke type. There were no gender differences seen in stroke outcome. Acknowledgement: The Indian Council of Medical Research Task Force Project. Disclosure: Dr. Kaur has nothing to disclose. Dr. Pandian has received personal compensation for activities with Intas Pharmaceuticals and Sanofi-Aventis as an advisor. Dr. Singh has nothing to disclose. Dr. Bansal has nothing to disclose. Dr. Paul has nothing to disclose. Dr. Singla has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Samuel has nothing to disclose.