Levels of soluble fibrin in severe septic patients given intravenous immunoglobulin

It is known that severe sepsis causes multiple organ failure and high mortality. Intravenous immunoglobulin (IVIG) is used for severe sepsis patients. The mechanism of IVIG is clearly unknown. Suggested, however, is the possibility that IVIG prevents organic injury by suppressing the inflammation. Soluble fibrin (SF) is intermediate between fibrinogen and fibrionoligomer. It is better than fibrinogen as the material for thrombin. IVIG is used as one of the effective factors for repair of the damaged vascular endothelium. In this study we used SF as a marker of severity of illness in patients with or without IVIG and compared the levels of SF in two groups.