GW28-e0629 Interleukin 37 attenuates osteo-fibrotic responses mediated by the advanced glycation end-products modified low density lipoprotein in human aortic valve intersitial cells

Calcific aortic valve disease is one of leading cardiovascular diseases, and pharmacological intervention is currently unavailable. Increasing number of studies implicate aortic valve interstitial cells (AVICs) play a critical role in the pathogenesis of calcific aortic valve disease. IL-37 is