Severe proteinuria, sustained for 6 months, induces tubular epithelial cell injury and cell infiltration in rats but not progressive interstitial fibrosis

Background. Sustained proteinuria is reported to be very harmful to the tubulointerstitium, leading to severe interstitial injury. However, it remains unclear whether sustained proteinuria itself is responsible for Introduction severe interstitial injury because, in the previously reported models, the development of factors other than Sustained proteinuria is reported to have pathogenic proteinuria in tubulointerstitial lesions could not be importance in the progression of chronic renal failure excluded completely.