Spontaneous Clearance of Drug-Resistant Chronic Hepatitis C Virus Infection.

Chronic hepatitis C virus (HCV) infection is characterized by stable HCV RNA levels. Spontaneous clearance or even temporary control of viremia to undetectable levels are almost never observed in long-term chronic infection. Here we report the spontaneous control of HCV viremia in a patient following virological relapse with emergence of a NS5A drug-resistant virus after therapy with sofosbuvir and velpatasvir.