Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME

Zuzana Honetschlägerová,Kento Kitada,Zuzana Husková,Alexandra Sporková,Libor Kopkan,Marcela Bürgelová,Šárka Varcabová,Akira Nishiyama,Sung Hee Hwang,Bruce D. Hammock,John D. Imig,Herbert J. Kramer,Petr Kujal,Zdeňka Vernerová,Ludek Cervenka

Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME

2013

Zuzana Honetschlägerová
Kento Kitada
Zuzana Husková
Alexandra Sporková
Libor Kopkan
Marcela Bürgelová
Šárka Varcabová
Akira Nishiyama
Sung Hee Hwang
Bruce D. Hammock
John D. Imig
Herbert J. Kramer
Petr Kujal
Zdeňka Vernerová
Ludek Cervenka

Objective The present study was performed to investigate in a model of malignant hypertension if the antihypertensive actions of soluble epoxide hydrolase (sEH) inhibition are nitric oxide (NO)-dependent.

Keywords:

Angiotensin II
Nitric oxide synthase
Internal medicine
Epoxide hydrolase 2
Medicine
Endocrinology
Epoxide Hydrolases
Renin–angiotensin system
Nitric oxide
Diabetes mellitus
Kidney
Renal function
Endogeny

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